High mucosal cytomegalovirus DNA helps predict adverse short-term outcome in acute severe ulcerative colitis
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چکیده
منابع مشابه
Acute severe ulcerative colitis: timing is everything.
The idiopathic inflammatory bowel diseases comprise mainly two types of intestinal disorder, Crohn disease and ulcerative colitis. The clinical course is marked by exacerbations and remissions that occur spontaneously in response to treatment or intercurrent illness. The disease affects approximately 240,000 patients in the UK. Acute severe ulcerative colitis is a medical emergency; prompt effe...
متن کاملMucosal bacteria in ulcerative colitis.
Ulcerative colitis (UC) is an acute and chronic inflammatory bowel disease of unknown aetiology, although bacterial species belonging to the normal colonic microbiota are known to be involved in its initiation and maintenance. Several organisms have been linked to the disease; however, mucosa-associated bacteria are more likely to be involved than their luminal counterparts, due to their close ...
متن کاملControversies in mucosal healing in ulcerative colitis.
As clinicians we would all agree that the goal for our patients is to induce remission, which is usually defined as symptom resolution. Restoring continence and absence of rectal bleeding would be signs that the mucosa is at most minimally inflamed if not healed. However, there have not been any data to confirm that symptomatic improvement alters the natural history of the disease, nor decrease...
متن کاملRectal mucosal histamine release in ulcerative colitis.
1. Rectal dialysis in vivo was used to assess rectal mucosal release of histamine in patients with ulcerative colitis and in control subjects. 2. Rectal mucosal histamine release was significantly increased in ulcerative colitis, whether the patients were in remission or relapse. The highest values were found in active colitis, but in several such patients histamine release was within the contr...
متن کاملIncreased expression of DNA methyltransferase-1 in non-neoplastic epithelium helps predict colorectal neoplasia risk in ulcerative colitis.
AIMS To clarify the possible significance of increased expression of DNA methyltransferase (DNMT)-1 in the tumorigenesis of colorectal neoplasia in ulcerative colitis (UC) and to clarify whether analysis of DNMT1 expression in non-neoplastic epithelium can contribute to the prediction of increased risk for UC-associated neoplasia. METHODS Sixty-two patients with long-standing and extensive UC...
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ژورنال
عنوان ژورنال: Intestinal Research
سال: 2020
ISSN: 1598-9100,2288-1956
DOI: 10.5217/ir.2020.00055